Great advice: Yubikey with Keepass. YubiKey, a dedicated hardware the size of a small USB dongle designed to offer two-factor authentication. With the use of the Challenge-Response key provider plugin for KeePass, it is possible to set up a YubiKey such it will have to be plugged into a USB port for the password database to be decrypted.

Yubico | Trust the Net with YubiKey Strong Two-Factor Authentication

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